MAGNESIUM CARBONATE (UNII: 0E53J927NA) (CARBONATE ION - UNII:7UJQ5OPE7D)ģ55 mL in 1 BOTTLE Type 0: Not a Combination Productġ77 mL in 1 BOTTLE Type 0: Not a Combination Product 2010 59(4):441–51.Aluminum hydroxide and magnesium carbonate liquidĪLUMINUM HYDROXIDE (UNII: 5QB0T2IUN0) (ALUMINUM HYDROXIDE - UNII:5QB0T2IUN0) The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and patients with GORD. 2009 58(7):904–9.īeaumont H, Bennink RJ, de Jong J, Boeckxstaens GE. Paradox of gastric cardia: it becomes more acidic following meals while the rest of stomach becomes less acidic. The acid pocket: a target for treatment in reflux disease? The American journal of gastroenterology. Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study. This suggests that Gaviscon main effectiveness relates to its co-localisation with and displacement/neutralisation of the post-prandial acid pocket, rather than preventing reflux.Ĭamilleri M, Dubois D, Coulie B, et al. However, the number and spatial distribution of reflux events within the oesophagus are similar. Gaviscon Double Action Liquid is more effective than an antacid without alginate in controlling post-prandial oesophageal acid exposure. There were no differences in the number of reflux events (acid or weakly acidic) or the number of proximal reflux events (15-17 cm above the LES) with either study medication. ![]() Gaviscon studies had significantly less distal oesophageal acid exposure and greater nadir refluxate pH in the 30-150 min post-prandial period than antacid studies. The primary outcome was distal oesophageal acid exposure secondary outcomes were number of reflux events, proximal extent of reflux, nadir pH of the refluxate, mechanism of reflux and reflux symptoms scored with a validated instrument. ![]() In a double-blinded randomised crossover design they then took Gaviscon or CVS brand antacid, each with ~18 mmol/L acid neutralising capacity. ![]() To compare the effectiveness of Gaviscon Double Action Liquid to an equivalent strength antacid without alginate in controlling post-prandial acid reflux in GERD patients.įourteen GERD patients undertook two 3.5-h high-resolution manometry/pH-impedance studies during which they ate a standardised meal. Recent studies have shown that Gaviscon Double Action Liquid (a combination alginate-antacid) administered post-prandially co-localises with the acid pocket, the 'reservoir' for post-prandial acid reflux.
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